Monthly Archives: February 2019

Brimonidine tartrate for glaucoma treatment

Introduction: Glaucoma is a disease of the eyes. This is a condition in which intraocular pressure is increased. This will lead to a really painful situation. The eyes will look like they are coming out of the eye sockets. If the glaucoma is not treated in the right manner, it can lead to permanent damage to the eye. In some severe cases, glaucoma can lead to blindness. There are two ways by which the pressure inside the eyes can be reduced. It’s by increasing the drainage of aqueous humour or decreasing the production of the aqueous humour.

Action: Glaucoma is what is brimonidine tartrate eye drops are used for. These decrease eye hypertension by decreasing the production of aqueous humour. It has a mechanism which will allow it to reduce the production and increase the flow as well. A pathway called the uveoscleral pathway is used by this drug. The decrease of production is the main effect which is even prevalent on lower doses while the increased drainage is only visible at higher doses. It will directly go to the inner part of eyes because of its rapid penetration and produce its effects. Due to rapid penetration could have been some side effect but it is not the case as once it reached the systemic circulation really rapidly broken down and in almost two hours it is reduced to half of its original quantity. The amount will not be enough to produce the effect in other parts of the body.

Dosage: Brimonidine tartrate ophthalmic solution for glaucoma treatment can be started at two times a day dosage, It is seen by research that there will be no benefits of using dosage three times a day as compared to two times a day. When the eye drops are inserted in the eyes the effect will start within one hour of insertion while the peak effect is reached within 2 -3 hours. The effect will start to diminish after that but there will be enough effect to make two times a day dose possible,

Protection of eyesight:  Brimonidine tartrate ophthalmic solution fis evident from research that the brimonidine tartrate will decrease the pressure in the eyes and also it has been seen that it has some extra benefits. Brimonidine tartrate ophthalmic solution will protect the ocular nerve from damage. The protection is because of the rapid onset of action and prolonged effect. Research suggests that it can even be used in cases where there is a need for nervous system protection in any part of the body.

Brimonidine tartrate in the market:

The main brand for brimonidine tartrate is Alphagan P. It is manufactured and marketed by Allergan. It contains the active ingredient 0.1% and at pH of 7.7 It was introduced in a different way as it had a concentration on 0.2% and was having pH 6.4 Later in research, it was seen that both concentrations produced the same effect but there were more chances of side effects with higher concentrations.

Brimonidine tartrate ophthalmic solution side effects:

It can sometimes cause itchy eyes, blurred vision, feeling like something is in your eye, and even dry eyes. There are rare chances but sometimes it can go inside the body and produce systemic effects like stomach upset and allergic reactions.